In terms of medication treatment for PTSD, there's very little indicated other than the SSRIs, the selective serotonin reuptake inhibitors.
What we would tend to do, as clinicians, is we would try to treat the comorbidities aggressively, so including treating major depression, other anxiety disorders and using general protocols that have been established for treating depression. We would start first with an antidepressant and follow them over time. If they do not respond, we might increase the dose, and if they don't respond, we might add a different class of antidepressant. If they still do not respond, we could add an atypical antipsychotic or mood stabilizer.
Are those the types of details you're looking for?