As a clinician and a psychiatrist—it's also done by psychologists when we're doing a diagnosis, but probably more so as a psychiatrist—we look at the entire person and do a complete medical history. Part of it would be looking at exposures. I'm not an expert in mefloquine; however, I've read about it. Obviously some of my patients have used it, or were prescribed it during their service, I should say.
In general, however, in medicine we try to find the most probable condition the person is suffering with as opposed to trying to find multiple probabilities. For example, somebody might have taken mefloquine, but they were also deployed to an area where they were exposed to significant traumatic events, and are reliving those events. Personally, as a clinician, I would approach it by saying, “It sounds to me like the symptoms you're presenting with are probably post-traumatic stress disorder. However, there are other things that might have contributed to it. Let's try the treatments that we know work well and see how you do.” If they fully recover from the standard treatments, then most likely we have the correct diagnosis. If, however, somebody is not responding to treatment after six months, then I start getting concerned, i.e., is it the right treatment?