I think you need a scientist to design your study, so I don't really have an answer to that question.
Obviously a scientific approach would be good and a rigorous model of looking at the various options. Again, I think there is lots of evidence that we need both of those, at least case-study-type evidence. I don't think the data has been collated on the other, but I may be wrong. I don't know. I can't answer the question.