I'm not sure exactly what you're getting at. If you were in a pre-approval process, where you have to bring a new substance forward and you have to go through a process, you would have to bring sufficient evidence to meet the threshold to indicate its safety.
One of the other parts of this discussion is highlighted by this question of definition. I think there is a great difference in the terms that we use and of our understanding of science, risk assessment, and hazard. Rarely do we see any forum convened for our kinds of organizations to sit down and have that kind of discussion to get the nomenclature right. Part of that communication is about whether we are even talking about the same thing in the same way, so—