I go back to your concept of evidence-based stuff. If a compound is going to be tested and you test it for the strongest people in your society, then you're not fulfilling the testing requirement you want it to be, namely, safe. You should be looking at those who are most vulnerable. For example, you don't test a compound against eels because they can tolerate just about anything; but you test it against trout, a delicate creature, so your testing becomes much more rigorous.
I used one example from Health Canada and some of its risk analysis of compounds, and how it's calculated. For native people, we eat a heck of a lot more fish than that.