A number of issues, such as infrastructure and economic security, are regional, but the base is the state. When Pascal Lamy, the former head of the WTO, was asked what he had learned, he said he used to think we needed global solutions to national problems, but he now realized we need national solutions to global problems. You need to build the building blocks.
Take West Africa; you need regional approaches, but boy, it was great to help stabilize and improve Ghana and Senegal because they then became pathfinding nations for anglophone and francophone West Africa. If we're going to focus, regional engagement is good, but country focus is essential.