I think the first thing, which is well known in the sciences, is that we know the immediate benefits of advances in technology, but we don't know the consequences a long way down the line. Jared Diamond makes the point that when automobiles came out, everybody was relieved. We didn't have piles of horse manure and dying horses in the streets, yet obviously there were subtle effects down the line. Technology has unforeseen consequences. Every technological advance has unforeseen consequences. The trouble is that we don't know the consequences until a while down the line.
The second thing is that transformative technological fixes seem to be becoming harder. There are a whole range of ways you can explain that. Possibly it's the way the patenting system works, or possibly it's because of crises multiplying faster than the fixes. This essentially makes for much more unpredictability.