However, if I can just add to that, the history of the indications for these drugs is such that you get it into the marketplace, you find that it works for the initial indication, but you soon find with off-label use that it has many other, completely unexpected ramifications. So it's not always possible to predict which off-label use is going to come up in your post-marketing plan. That's the good news.
The bad news, as you pointed out, is that it may occur in an unrestricted, unorchestrated way, and you have to strike a balance between these two. But I would hate to see that off-label use was prevented, particularly since—in response to another question—many of these indications are for rare diseases or uncommon conditions, and clinical trials would not ordinarily be conducted for those indications. They're either too long or too expensive, and you wouldn't want to prevent the use of these drugs in an off-label situation when it was quickly discovered that it was effective. The balance has to be struck in the legislation and the handling of this issue.