The mechanisms in terms of how home hemodialysis improves these health outcomes are that...normally when a patient with end-stage renal disease uses conventional hemodialysis three times a week in a hospital setting, the renal replacement therapy they get brings back about 15% of their renal functions. With home hemodialysis, they can dialyze more frequently. They dialyze nocturnally, which brings up their renal replacement to about 50% to 60%. That means there are fewer toxins in the blood, and hence they can conceive, they can bring a pregnancy to term,and all of these other health outcomes improve. Our kidneys work 100% of the time. When someone has end-stage renal disease, they may have no residual kidney function, and again, conventional therapy only gives them about 15% of that function back.
It's simply the fact that they can do dialysis more frequently in the home.