Thank you.
My name is Cécile Tremblay, I am an infectious disease specialist and medical microbiologist at the Centre hospitalier de l'Université de Montréal. I hold the Pfizer University of Montreal chair on HIV translational research.
I have been working for decades on correlates of protection that could be used for vaccine development in HIV. This goal has long eluded us for HIV, so we've been thrilled to see the rapid development of viral-effective vaccines against COVID-19 in such a short period of time.
Several challenges persist. Vaccines do not stop pandemics; vaccinations do. Three factors will determine if herd immunity can be achieved in Canada through vaccination.
First is the availability of vaccine supply. Canadian researchers have been working hard on developing new vaccines. This work has been supported by the Canadian government through CIHR and other funding mechanisms. However, the time frame for the development of a new vaccine amenable to clinical trial in Canada is unlikely to yield products available for us in 2021.
I'm talking about the homegrown vaccines in Canada. These research efforts, though, should continue to be supported, as they may become useful if the pandemic persists, or if variants render our present vaccines obsolete.
At the moment, we have to rely on existing vaccines, which are in short supply not only in Canada, but throughout the world. Because of our deficient Canadian vaccine manufacturing infrastructure, we have had to rely on the importation of vaccines produced elsewhere with all of the delays that creates.
The lessons learned from previous pandemics had identified the need to produce vaccines in Canada as a priority, as part of a pandemic preparedness plan. Unfortunately, little was done and although we have had some companies manufacturing vaccines in Canada such as Sanofi Pasteur in Toronto and GSK in Quebec City, the capacity for large-scale production is limited.
The recent initiative of the federal government to develop a vaccine manufacturing facility in the Royalmount district in Montreal is commendable. Other facilities associated with research centres are also being created, such as the one in Saskatoon.
However, if we want to develop sustainable infrastructure for vaccine development and production in Canada, we must also support the presence of a variety of pharmaceutical industries, from homegrown biotechs such as Medicago in Quebec City, to big pharma. This will maintain the scientific expertise in Canada and avoid the brain drain of our young researchers to the U.S.
This means reversing an unfortunate trend over the last decade. In 2007, AstraZeneca and Bristol Myers Squibb shut down their manufacturing operations. In 2010 Johnson & Johnson and Merck's research centre in Montreal closed. Several other companies such as Pfizer, Abbott, and other research facilities that were based in Quebec were also relocated abroad.
If we want to make sure that we have sufficient vaccine supplies for the next pandemic, then we need to have an infrastructure that includes both a government-administered manufacturing capacity and a strong pharmaceutical industry presence.
The second factor in achieving herd immunity is the ability to establish mass vaccination programs that are accessible to the entire population. From what we can observe in Quebec, this seems to be quite well organized.
The third factor is vaccine hesitancy. This is not specific to COVID-19. Misinformation on vaccines has been circulating for decades, and has accelerated in recent years on social media. COVID-19 has intensified conspiracy theories, which have instilled fear in a significant proportion of the population.
To achieve herd immunity it is believed that 75% to 85% of the population needs to be vaccinated. At the moment a good percentage of the population is eagerly awaiting their vaccine. These are the low-hanging fruit. The challenge will be to reach out to those who are hesitant and not necessarily against vaccination, but who need to have their questions answered.
So far it is not clear to me what the communication plan is. People who are hesitant about getting vaccines are spread throughout society across all ages and socioeconomic strata. Specific communication strategies must be developed to address their various concerns.
Finally, phase three vaccine clinical trials usually exclude certain populations, such as immune-compromised and HIV-positive people, transplant patients, cancer patients receiving immunosuppressive therapies, and pregnant or breastfeeding women. However, we know that these populations could benefit from vaccines, but we are always in the grey zone, because data has not been collected. It could be, because of their immunosuppression, that their antibody response may not be as high or effective. We might need to use a different strategy, such as adding booster doses.
Usually researchers initiate research projects, like I do, to test vaccines in these populations. They apply for grants and, if they are lucky, they get funded. There's always a problem in accessing the product that we want to test to conduct these clinical trials.
With phase 4, this is particularly true when the supply is limited, such as the case right now, so testing new vaccines in these various populations should not be left to individual initiatives. It should be mandated by the government, and resources as well as vaccines should be available automatically to conduct these phase 4 trials once the vaccines are approved.
In the midst of this devastating pandemic, vaccines are the shining light on the horizon. Let us learn from previous pandemics and build a durable infrastructure encompassing research and development and manufacturing and distribution so that we are ready for the next time.