I think Ms. Rempel Garner asked a key question. Canadians want to know, is this a good vaccine? Should I recommend it for my parents, if they have the opportunity to get this vaccine, or for my brother, who has a lot of underlying medical problems? I think the answer is yes. Unfortunately, in this meeting it's about as clear as mud, as far as I'm concerned, because there are so many different numbers out there. I think part of the confusion is the difference between “efficiency” and “effectiveness”.
I'll direct this to you, Dr. Quach-Thanh, because I think you know the numbers pretty well. My understanding of the efficiency comes from the phase three randomized control trial, where you had either the AstraZeneca vaccine or the placebo. Overall, the efficacy was 62%, but it was something like 40% in people over 65. However, to my understanding, I think in North America it showed 72% efficiency, and with half the first dose 90% efficiency.
That's from a randomized control trial, where you pre-select the people. In the actual real-world experience, the effectiveness has actually shown AstraZeneca looking better. There was the study by Hung and Poland in The Lancet, with 17,000 people. This was the one where they looked at giving the booster four months afterwards. They found an 81% effectiveness, including in the elderly. The other numbers I saw showed, with a four-month interval in spacing, 76% to 82%. They were certainly a lot better numbers than the 62% and the 40%. If you look at the efficiency or efficacy from the actual trial with AstraZeneca in preventing deaths, it was 100% efficient or effective in preventing death. In hospitalizations, the Scottish study showed 94%, but you're not going by those numbers.
Is that about right? In the actual study by AstraZeneca, nobody who got the vaccine died, and giving it four months apart was about 80% effective in preventing clinical illness. Is that right? As well, what is the hospitalization rate?