That's actually a very good question.
We don't have research trials per se to say whether you actually mount an immune response over the age of 45. I can definitely respond because I'm also the head of colposcopy in my hospital. If a woman comes to me because she has a precancerous lesion due to an HPV virus, whether it be cervix or vulva, I absolutely offer her the HPV vaccine if she would like to receive it, no matter what her age.