Mr. Chair, thank you very much. I am happy to kick off with the first statement. Then I will turn it over to my colleague Dr. Kaushic from the Canadian Institutes of Health Research so she can provide her statement.
We are pleased to be here today to contribute to your important study on antimicrobial resistance, AMR.
AMR is one of the world's top 10 most serious health threats. Microbes, including bacteria, viruses, fungi and parasites, can change in ways that make antimicrobial drugs less effective. This is a natural process, but it is accelerated when antimicrobials such as antibiotics are used too often or inappropriately in people, animals and crops.
Canada has over 20 years of experience in integrated AMR surveillance. The Canadian antimicrobial resistance surveillance system, CARSS, tracks trends in resistance and antibiotic use across humans, animals, food and the environment in order to guide national action.
Globally, AMR is now a leading cause of death, causing an estimated 1.14 million deaths in 2021 alone. In Canada, in 2018, nearly 15 people per day were estimated to have lost their lives to antimicrobial-resistant infections. The impacts are disproportionately felt in low-middle income countries, and the threat of AMR transcends borders due to the global movement of people, animals and goods.
The impact of AMR on Canadians is clear, with 26% of infections already resistant to first-line antimicrobials. The Public Health Agency of Canada estimates that one resistant infection is detected for every 220 patients admitted to acute-care hospitals. In 2018, AMR was estimated to have caused 5,400 deaths, cost the health care system about $1.4 billion and reduced GDP by $2 billion. Data also suggests that there are disproportionate AMR impacts on some populations in Canada, including long-term care residents.
Because AMR is a One Health issue where resistance can develop and spread among people, animals, food systems and the environment, multi-jurisdictional and multisectoral collaboration to address AMR is essential.
Domestic action on AMR is coordinated by PHAC in collaboration with other federal departments, provinces and territories, indigenous peoples, multi-sectoral stakeholders and other partners.
In 2023, the federal Minister of Health and Minister of Agriculture and Agri-Food jointly released the pan-Canadian action plan on AMR. The action plan provides a five-year blueprint for strengthening Canada’s collective response and leadership on AMR using a one health approach.
We are halfway through implementing the action plan and continue to make progress. Later this winter, PHAC will be releasing a year-two progress report. It is coming soon and will detail achievements across areas of action, such as research and innovation, stewardship and leadership.
A few weeks ago, the Government of Canada participated in the annual World AMR Awareness Week. During that week, we had the opportunity to highlight some of our achievements to date, reinforcing this year’s theme for World AMR Awareness Week; we are acting now, protecting our present and securing our future.
Canada continues to strengthen AMR and antimicrobial use surveillance; however, the landscape is evolving. Trends for several prioritized human AMR pathogens are increasing in Canada, including resistant infections commonly seen in hospitals, as well as drug-resistant sexually transmitted infections.
Strengthening antimicrobial stewardship, maintaining strong infection prevention and control, and sustaining immunization efforts are all essential to reducing the burden of AMR and preserving the effectiveness of the treatments we have today. PHAC is working across jurisdictions and with international partners to advance these actions, as well as planning for emerging priorities such as AMR linkages to health security.
This work extends beyond Canada's borders. Over the past few years, the Government of Canada has committed to several international AMR initiatives, including the 2024 United Nations General Assembly political declaration on AMR. Canada is working with global partners to advance the goals set out in that declaration, recognizing that AMR threats move across countries and continents. International progress helps limit the spread of resistant organisms and, in turn, protects the health of Canadians at home.
Thank you again for the opportunity to speak with the committee about this important issue today. The Public Health Agency of Canada recognizes that AMR is a growing threat that requires sustained attention and coordinated action.