I don't want to take too much time to get into the details of specific clauses, but you could think of the entire ISDS as a ratchet, because you are locking in your space to pass laws and make regulations, without this looming risk of a potentially very significant financial cost to the taxpayers.
For example, towards the end of the Conservative government's term, there were proposals for new, tough anti-corruption rules. According to The Globe and Mail, those were reportedly subject to behind-the-scenes warnings that NAFTA ISDS claims would be brought against Canada if the government proceeded with those new rules. I haven't followed the file closely, but I certainly haven't seen any public reports that the government proceeded with those rules. I'm not saying that was due to ISDS, but just that it's an example of how policy interests can conflict with this very potent system.