Sure. When somebody is taken into custody, they will often face loss of job, relationship, children—if there's any kind of ongoing family law court proceeding—and housing.
One need do no more than read the Balfour and Young decision, which talks about some of the horrible consequences. In Balfour and Young, there were two defendants. The charges were stayed against one and the other was acquitted. This was a post-trial proceeding, which was just a “cost against the Crown” application. It was, in effect, a public inquiry conducted into the bail system in northern Manitoba after both accused were already finished with their trials. Neither of them was guilty. Both faced horrible consequences, as do many others when they're denied bail and the charges are ultimately withdrawn or when they're found not guilty.