Certainly, if I can speak out of self-interest, western Labrador would be good. That's where I grew up.
Looking at the list of regions, we obviously see that Newfoundland and Labrador, British Columbia and Saskatchewan are missing. If there could be at least one designated region in each province, I think it would help francophone minority communities in those provinces not feel as left out by the regulations.
Again, what's in the official languages regulations dealing with part IV of the Official Languages Act would help, because percentage comes into play in the case, for example, of western Labrador. Obviously, it's not a large community, but it's also a very small region with few inhabitants. That would give it a chance to be resilient as far as the entire part IV is concerned.
That's what I would do. Unfortunately, a Ph.D. in political science doesn't come with a magic wand.