We don't know. We don't have enough knowledge about this. Most people would have had some form of treatment. Whether it's because of the treatment or natural history, it's hard to tell what is causing that. These are longitudinal studies that would take 10 years, 20 years, 40 years sometimes to get that knowledge.
The other issue is the issue of suicide. It does happen, but again, we don't know when it's going to happen or if it's going to happen. We have good knowledge about the factors that increase the risk.
The third point is related to medication and whether someone would respond or not and even without responding to a treatment, whether they would recover naturally. We know, for example, with depression that people who do not have any treatment for depression or depressive episodes will eventually recover from it. We don't know exactly when.
The other part of the issue, the second big concept related to the irremediable nature of the illness, is that even for individuals who have the symptoms and still experience the episodic nature of the illness, there is a recovery approach that we take on to help individuals live with the illness. Because of that lack of inevitable and progressive course towards death, in some sense, we have the luxury and the hope of working with someone, even if they are refusing treatment. I can think of specific examples of individuals and patients I have seen in the last week or so who are refusing treatment but are still coming to see me, because my point to them is that I will be there if they come back to see me. We will keep working on talking about the issues related to treatment or recovery, and about how to live with the illness, so that the illness doesn't become—