I don't know that we need to re-examine the entire scientific process, but I think there are aspects that warrant a revisiting.
Take, for example, randomized controlled trials. When we think about that in the context of psychedelics, they are measuring a very specific pharmacological action. What they don't measure are all of the kinds of interactions with the environment and all of the kinds of personal and emotional interactions that occur when someone consumes psychedelics.
Indigenous ceremonies don't treat psychedelics like a randomized controlled trial. That completely reorients the interaction and the experience. I think listening and learning about why those ceremonies exist and what functions they serve could be very instructive for imagining what meaning we are trying to extract from that pharmacological reaction.