Yes, thank you. This is an extremely important point. There are two papers, specifically one from Health Affairs from 2016 and one in the Journal of the American Medical Association, also from 2016, I think, which showed a very distinct decrease in the number of prescription pills issued per physician in U.S. states that have medical cannabis programs. The number of opioid prescriptions per physician dropped by 1,800 in the states that enacted medical cannabis programs. The result of that is what was reflected in the JAMA paper, which was that there were 25% fewer unintentional opioid overdose deaths in states that had enacted medical cannabis programs, compared to the number in states that had not enacted cannabis programs.
The decrease in the number of prescriptions per physician was reflected in a significant drop in the number of unintended deaths from opioid overdose. That is a huge problem in the U.S. In 2017, I think 72,000 people died from unintended opioid overdoses and drug interactions. Something as simple as aspirin or non-steroidal drugs—indometacin of course being a prescription drug and quite an aggressive one—kill about 15,000 to 20,000 people in the U.S. We think of these things as being innocuous, and yet they are not. This is most important.