Basically I would say that in terms of the status of the evidence of long-term psychiatric effects of mefloquine, we have case reports. We can't.... Despite studies of hundreds of thousands of subjects, we can't demonstrate that this is confirmed, and if there are these types of effects, we presume that they are actually very rare.
Ultimately, the choice of mefloquine versus other drugs is going to be an individual type of choice. Individuals will have different risk factors where you might want to choose one drug over the other for a whole variety of reasons. Whatever the problems are with mefloquine, they're not of a nature that you would want to take that option off the table entirely, in my opinion.