Thank you so much, and thank you for the invitation to be here today. It's wonderful to see everybody.
My name is Isaac Bogoch, and I’m an infectious diseases physician and scientist, as well as a professor of medicine based out of the University of Toronto. I recently spoke about antimicrobial resistance, or AMR, at the Standing Committee on Science and Research, and I'll be making many of the same points here. I regularly treat drug-resistant infections in my clinical practice, and my research focuses on how these organisms spread around the world, mainly through human mobility patterns. I’m grateful that you're studying this topic, because it has a tremendous negative impact in Canada and around the world.
As you've heard, AMR arises from the misuse and the overuse of antimicrobial drugs, rendering them ineffective and causing substantial morbidity and mortality. I see this at the bedside as a clinician; I appreciate that some of you in the room are physicians as well, and you have dealt with this too. AMR leads to the delayed initiation of appropriate antibiotics, and it results in predictable negative consequences.
Interestingly, although many people might not be aware of this, about 70% of the global antibiotic consumption is in agricultural animals, and only 30% of the use is in humans. This imbalance underscores the importance of what we call the “one health” concept, which basically recognizes the interconnectedness of human, animal and environmental health; because of this, we need to take a collaborative and—pardon the buzzwords—truly cross-sectoral approach to combatting AMR, because it's a massive problem.
A recent study published in The Lancet estimated that there are about 4.7 million deaths per year in which AMR plays some role. To put that into context and perspective, that's more deaths than from HIV, TB and malaria combined; every country is impacted, but of course, lower-resource settings are disproportionately impacted.
We're not going to invent our way out of this issue by developing new drugs. In an arms race between creating new drugs and microbes adapting to these drugs, the microbes are going to win every time, as they've done in the past.
Canada, relative to the rest of the world, is doing well, but—pardon the pun—we're not immune. We have national strategies and regulations for antibiotic use. We have infection prevention and control initiatives that mitigate the impact of AMR spread in health care settings, but the uncomfortable truth is that we can do everything right in Canada and still fail. We know that AMR, like just about every other pathogen, doesn't respect political borders. We can see the development of resistant organisms on one side of the planet, and they move to Canada and elsewhere around the world through travel and trade.
While AMR is appropriately framed, as I mentioned, as a one health issue, I would also urge you to consider this a health security concern. As we saw during COVID-19, our supply chains for diagnostics and therapeutics are fragile, and they might be further strained by growing geopolitical instability. There is an ongoing war in Ukraine, for example, that could spread to other NATO countries. We already had two allies invoke Article 4 in 2025. For an example, in this conflict, up to 80% of the combat wound infections are resistant to conventional antibiotics. This would pose a serious risk should Canada be drawn in. In addition, Russia’s past biological weapons program is well known to have developed drug-resistant pathogens. At a time when Canada has pledged to raise security spending to 5% of GDP, failing to integrate AMR research and preparedness into that investment would overlook a critical threat.
Do you know what? I can't say this with a straight face. I was going to say it's not all bad—but it actually is. There are large surveillance programs to study and track AMR. The WHO which leads a big program. The U.S. CDC leads a big program. Of course, as you are well aware, major partners are massively scaling back funding, and global health leadership is imploding. This leaves us more vulnerable, but it also presents a major opportunity for Canada to fill the vacuum as a global leader in health care, public health and health security, with a focus on combatting AMR.
What is a smart path forward? We can take a true intersectoral approach, with a national and global perspective.
We can strengthen antimicrobial stewardship programs and infection prevention and control programs in Canada and abroad. This means not just in health care but also in agriculture and veterinary sectors.
We can enhance AMR surveillance in Canada and abroad. We don’t need to reinvent the wheel. These programs exist. We can just help support funding them.
We can invest in research and innovation in Canada and abroad—supporting public-private partnerships, enabling Canada to be self-reliant, supporting R and D for new diagnostics and therapeutics.
We can raise public awareness campaigns for various sectors on the dangers of the overuse and misuse of antibiotics.
We can then leverage the security aspect of AMR to fund many of these initiatives.
AMR isn’t a distant threat—it’s already here, and it endangers both Canadian and global health. We can act now, or we can face far greater consequences in the future.
Thank you very much for your time.